Answer: Enzymes are biocatalysts that accelerate biochemical reactions by lowering the activation energy. They work through the lock-and-key model and the induced fit model.
Enzymes speed up reactions by reducing the energy barrier, which allows reactions to occur faster at physiological temperatures. They are highly specific and regulate metabolic processes, such as digestion, cellular respiration, and DNA replication.
Examples:
Enzyme inhibitors, such as competitive inhibitors and non-competitive inhibitors, can either compete with substrates or alter the enzyme's shape, reducing its activity.
Answer: Detergents are surfactants that lower the surface tension of water, which helps to remove dirt, grease, and oil from surfaces. Their amphiphilic nature plays a significant role in their cleaning action.
Types of Detergents:
These properties make detergents highly effective in cleaning clothes, utensils, and surfaces in general.
Answer: Vitamins are organic compounds essential for various biochemical functions in the human body. They act as coenzymes or precursors of coenzymes, which help enzymes in catalyzing specific reactions.
Fat-soluble vitamins: These are stored in the body and are essential for various metabolic processes.
Water-soluble vitamins: These are not stored in the body and must be consumed regularly.
Answer: Antacids are basic compounds used to neutralize excess stomach acid (hydrochloric acid, HCl), which helps alleviate symptoms of acid reflux, heartburn, and indigestion.
Mechanism: Antacids work by reacting with the excess HCl in the stomach to form water and neutral salts, thus raising the pH in the stomach.
Common bases used:
The bases in antacids are designed to neutralize stomach acid without causing significant side effects, providing relief from acidity-related discomfort.
Answer: Aspirin (acetylsalicylic acid) is a widely used analgesic (pain reliever), antipyretic (fever reducer), and anti-inflammatory medication.
Mechanism of action: Aspirin inhibits the enzyme cyclooxygenase (COX), which is responsible for the production of prostaglandins. Prostaglandins are chemicals that promote inflammation, pain, and fever in the body. By inhibiting COX, aspirin reduces the synthesis of these inflammatory mediators.
Aspirin selectively inhibits COX-2, thus providing anti-inflammatory and pain-relieving effects without affecting the stomach lining as much as non-selective NSAIDs.
Applications: Aspirin is used for pain relief (headaches, muscle pain), reducing inflammation (arthritis), and fever. It also has an important role in preventing heart attacks by inhibiting platelet aggregation.
Answer: Insulin is a peptide hormone produced by the pancreas that plays a crucial role in regulating blood glucose levels. It promotes the uptake of glucose by cells, thus reducing blood sugar levels.
Insulin also inhibits the liver's production of glucose (glycogenolysis and gluconeogenesis), ensuring that blood glucose levels remain stable.
In diabetes, there is either insufficient insulin production or resistance to insulin, leading to elevated blood glucose levels.
Answer: Antibiotics are substances used to kill or inhibit the growth of bacteria. They are essential in the treatment of bacterial infections.
This resistance is a growing global concern, as it reduces the effectiveness of antibiotics and limits treatment options for infections.
Answer: Antihistamines are drugs used to treat allergic reactions, including hay fever, rashes, and insect bites.
Older antihistamines (e.g., diphenhydramine) can cross the blood-brain barrier and cause drowsiness, while newer antihistamines (e.g., loratadine) are designed to minimize this effect.
Answer: Sodium chloride (NaCl) is an essential electrolyte that helps maintain fluid balance, nerve function, and blood pressure in the human body.
Answer: Sodium bicarbonate and aluminum hydroxide are both used to neutralize stomach acid but differ in their mechanism and side effects.
Sodium bicarbonate: It is a fast-acting base that reacts with hydrochloric acid to produce water, carbon dioxide, and salt. However, it can lead to bloating, gas formation, and alkalosis (an imbalance in the blood's pH) if overused.
Aluminum hydroxide: It acts more slowly and is generally used in combination with magnesium hydroxide to balance side effects. It neutralizes stomach acid and forms aluminum chloride, which is not absorbed into the bloodstream.
While both antacids neutralize acid, aluminum hydroxide is gentler on the stomach and does not produce gas.
Answer: Aspirin (acetylsalicylic acid) is one of the most commonly used analgesic (pain-relieving), antipyretic (fever-reducing), and anti-inflammatory drugs. It has significant therapeutic effects, and its mechanism of action is well understood.
Mechanism of action: Aspirin works by inhibiting cyclooxygenase (COX) enzymes, primarily COX-1 and COX-2. These enzymes are involved in the conversion of arachidonic acid to prostaglandins, which are chemicals responsible for promoting inflammation, pain, and fever.
Side effects:
Despite these risks, aspirin is widely used for treating mild to moderate pain, fever, and inflammation, and is also used as a blood-thinning agent to prevent heart attacks and strokes.
Answer: Sodium chloride (NaCl) plays a critical role in maintaining various physiological functions, particularly in maintaining osmotic pressure, electrolyte balance, and nerve function.
Osmotic Pressure: Sodium is the primary extracellular cation and is essential for maintaining osmotic balance between cells and the surrounding fluid. The movement of water in and out of cells is regulated by sodium ions, ensuring that cells neither shrivel nor burst due to excess or lack of water.
Electrolyte Balance: Sodium chloride helps in regulating the osmolarity of body fluids. This is crucial for maintaining the balance of ions like sodium (Na⁺), potassium (K⁺), calcium (Ca²⁺), and chloride (Cl⁻) that are involved in cellular processes.
Nerve Function: Sodium ions are essential for the generation and transmission of nerve impulses. Nerve cells (neurons) rely on the movement of sodium and potassium ions across the cell membrane to generate an action potential, which transmits signals throughout the nervous system.
Blood Pressure Regulation: Sodium chloride influences blood volume and blood pressure. High sodium intake can lead to an increase in fluid retention, which raises blood volume and, subsequently, blood pressure. Excessive sodium consumption is linked to hypertension, a major risk factor for cardiovascular diseases.
Answer: Chemical preservatives are substances added to food to extend its shelf life by preventing the growth of microorganisms, oxidation, and spoilage. The major types of preservatives are:
Chemical preservatives are essential in modern food processing as they allow food products to remain safe for consumption over long periods, reducing food waste.
Answer: Sedative-hypnotic drugs are a class of drugs that depress the activity of the central nervous system (CNS), leading to relaxation, drowsiness, and ultimately sleep. They are primarily used to treat insomnia, anxiety, and seizures.
Mechanism of action: These drugs work by enhancing the effects of GABA (gamma-aminobutyric acid), an inhibitory neurotransmitter in the CNS.
Benzodiazepines: These drugs are often preferred because they are safer and have fewer side effects. They cause sedation, reduce muscle tension, and induce amnesia. They are commonly used to treat anxiety, seizures, and insomnia.
Barbiturates: Although effective, they have a higher potential for abuse, addiction, and overdose. They are rarely used now due to their dangerous side effects.
Side effects: Common side effects include drowsiness, dizziness, impaired coordination, and memory problems. Long-term use can lead to tolerance, dependence, and withdrawal symptoms.
Answer: Biochemical reactions play a critical role in maintaining homeostasis, which is the body's ability to maintain a stable internal environment despite external changes. Homeostasis involves the regulation of parameters like temperature, pH, blood glucose levels, and osmotic balance.
Enzyme-catalyzed reactions: Biochemical reactions, especially those involving enzymes, help regulate metabolic pathways that maintain homeostasis.
Temperature regulation: The body maintains a constant temperature of approximately 37°C (98.6°F) through processes like thermogenesis and sweating. Metabolic reactions, including those involved in energy production in the mitochondria, are also temperature-dependent.
Acid-base balance: The buffer systems in the blood, including the bicarbonate buffer system, help maintain the pH of the blood at approximately 7.4, ensuring that enzymes and biochemical reactions operate within their optimal pH range.
Water balance: The kidneys play a significant role in regulating water and salt balance by performing biochemical reactions that filter blood and produce urine, maintaining proper hydration and electrolyte levels in the body.
Answer: Caffeine is a methylxanthine compound found in coffee, tea, and various other beverages. It is a central nervous system (CNS) stimulant known for its ability to increase alertness and reduce fatigue.
Chemistry of Caffeine: Caffeine is chemically known as 1,3,7-trimethylxanthine. It is structurally related to adenosine, a nucleoside that promotes relaxation and sleep by binding to adenosine receptors in the brain.
Mechanism of action:
Effects on the CNS:
Answer: Antacids are basic substances used to neutralize excess acid in the stomach, helping treat conditions like acid reflux, heartburn, and peptic ulcers. The most common antacids contain sodium bicarbonate (NaHCO₃), magnesium hydroxide (Mg(OH)₂), aluminum hydroxide (Al(OH)₃), or calcium carbonate (CaCO₃).
Mechanism of action:
Significance: By neutralizing excess acid, antacids relieve the pain and discomfort associated with acidity, reducing symptoms of gastritis, gastroesophageal reflux disease (GERD), and peptic ulcers. They also promote the healing of ulcers and prevent damage to the stomach lining.
Side effects: Prolonged use of antacids, especially those containing aluminum or calcium, can lead to side effects such as constipation or kidney stones. Overuse of sodium bicarbonate can lead to an imbalance in blood pH (alkalosis).
Answer: Polymers are large macromolecules made up of repeating structural units called monomers, which are covalently bonded. They have a broad range of properties that depend on their molecular structure, making them versatile materials in various applications.
Structure of Polymers:
Properties of Polymers:
Applications:
Polymers are integral to modern life due to their versatility, low cost, and ease of manufacturing.
Answer: Antibiotics are compounds that kill or inhibit the growth of bacteria, used to treat bacterial infections in humans, animals, and plants. Their effectiveness depends on their ability to target specific components of bacterial cells without affecting human cells.
Mechanism of action: Antibiotics target various bacterial structures and processes:
Resistance: Bacterial resistance to antibiotics occurs when bacteria evolve mechanisms to evade the action of antibiotics. This may include the production of enzymes (e.g., beta-lactamases) that degrade the antibiotic, modification of target sites, or efflux pumps that remove antibiotics from the bacterial cell.
Answer: Hormones are chemical messengers produced by glands in the endocrine system. They travel through the bloodstream to target organs and tissues, regulating various physiological processes such as growth, metabolism, reproduction, and homeostasis.
Functions of hormones:
Effects of hormonal imbalance:
Answer: Antiseptics and disinfectants are both chemicals used to kill or inhibit the growth of microorganisms, but they differ in their application and effectiveness.
Antiseptics:
Disinfectants:
Answer: Cholesterol is a lipid molecule that is essential for the structure and function of cell membranes and the production of various hormones. It is synthesized in the liver and also obtained from dietary sources.
Functions:
Risks of excessive cholesterol: