1. Define the
following:
(a) Exocrine gland,
(b) Endocrine
gland,
(c)
Hormone.
Solution:
(a) Exocrine gland is
a gland that pours its secretion on the surface or into a particular region by
means of ducts for performing a metabolic activity, e.g., sebaceous glands,
sweat glands, salivary glands and intestinal glands.
(b) Endocrine gland is
an isolated gland (separates even from epithelium forming it) which secretes
informational molecules or hormones that are poured into venous blood or lymph
for reaching the target organ because the gland is not connected with the target
organ by any duct. Therefore endocrine gland is also called ductless gland e.g.
thyroid gland.
(c) Hormone is a substance that is manu-factured and secreted
in very small quantities into the blood stream by an endocrine gland or a
specialized nerve cell and regulates the growth or functioning of a specific
tissue organ in a distant part of the body e.g insulin.
2. Diagrammatically indicate
the location of the various endocrine glands in our
body.
Solution:
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3. List the hormones secreted
by the following:
(a)
Hypothalamus
(b) Pituitary
(c) Thyroid
(d)
Parathyroid
(e) Adrenal
(f) Pancreas
(g) Testis
(h) Ovary
(i) Thymus
(j) Atrium
(k) Kidney
(l) G-l Tract.
Solution:
(a) Two
types of hormones are produced by hypothalamus : releasing hormones (that
stimulate secretion of pituitary hormones) and inhibiting hormones (that inhibit
secretion of pituitary hormones).
These hormones are:
(b) Different parts of pituitary secrete different hormones.
Hormones
secreted by anterior lobe of pituitary are:
(c) Thyroid secretes 3 hormones:
(d) Parathyroid gland secretes a single hormone called parathormone (PTH) or Collip’s hormone.
(e) Adrenal glands have two regions, namely, outer adrenal cortex and inner
adrenal medulla. Both these regions secrete different hormones.
Hormones of
adrenal cortex are grouped into three categories:
(f) Pancreas secretes following hormones:
(g) Testis secretes androgens such as testosterone.
(h) Ovary secretes:
(i) Thymus secretes thymosin hormone.
(j) Atrium secretes atrial natriuretic factor (ANF).
(k) Kidney secretes:
(i) Renin (ii) Erythropoetin
(l) G.I. tract secretes :
4. Fill in the
blanks:
Hormones
Target gland
(a) Hypothalamic hormones
………………..
(b) Thyrotrophin (TSH)
………………..
(c) Corticotrophin (ACH)
………………..
(d) Gonadotrophins (LH, FSH)
………………..
(e) Melanotrophin (MSH)
………………..
Solution:
(a) Pituitary
(b) Thyroid
(c) Adrenal cortex
(d) Gonads -Testes in male
and ovaries in female
(e) Skin.
5. Write short notes on the
functions of the following hormones:
(a) Parathyroid hormones (PTH)
(b) Thyroid hormones
(c) Thymosin
(d)
Androgens
(e) Estrogens
(f) Insulin and
Glucagon.
Solution:
(a)
Parathyroid hormone increases the level of calcium and decreases the level of
phosphate in the blood.
(b) Thyroid gland secretes three hormones: thyroxine,
triiodothyronin and calcitonin. Thyroxine and triiodothyronin control the
general metabolism of the body, promote growth of body tissues and stimulates
tissue differentiation. Calcitonin regulates the concentration of calcium in the
blood.
(c) Thymosin is secreted by thymus. It accelerates cell division,
stimulates the development and differentiation of T-lymphocytes and also hastens
attainment of sexual maturity.
(d) Androgens are secreted by testis. They
stimulate the development of male reproductive system, formation of sperms,
development of male accessory sex characters and also determines the male sexual
behaviour and the sex urge.
(e) Estrogens are secreted by ovaries. They
stimulate the female reproductive tract to grow to full size and become
functional, differentiation of ova and development of accessory sex
characters.
(f) Insulin is secreted by the |3-cells of the pancreas. It
lowers blood glucose level, and promotes synthesis of proteins and fats.
Glucagon is secreted by the a-cells of the pancreas. It increases the level of
glucose in the blood.
6. Give example(s)
of
(a) Hyperglycemic hormone and hypoglyce-mic hormone
(b)
Hypercalcemic hormone
(c) Gonadotrophic hormones
(d) Progestational
hormone
(e) Blood pressure lowering hormone
(f) Androgens and
estrogens.
Solution:
(a)Glucagon,
Insulin
(b) Parathormone (PTH)
(c) Follicle stimulating hormone (FSH) and
Luteinizing hormone (LH)
(d) Progesterone
(e) Atrial natriuretic
factor
(f) Testosterone and Estradiol.
7. Which hormonal deficiency
is responsible for the following:
(a) Diabetes meilitus
(b) Goitre
(c)
Cretinism.
Solution:
(a)
Insulin
(b) Thyroxine and Triiodothyronine
(c) Thyroxine and
Triiodothyronine.
8. Briefly mention the
mechanism of action of FSH.
Solution: (Folliclestimulatinghormone)being
glycoprotein is insoluble in lipids, therefore,
cannot enter the target
cells. It binds to the specific receptor molecules located on the surface of the
cell membrane to form hormone – receptor complex. This complex causes the
release of an enzyme adenylate cyclase from the receptor site. This enzyme forms
the cell cyclic adenosine monophosphate (cAMP) from ATP. The cAMP activates the
existing enzyme system of the cell. This accelerates the metabolic reactions in
the cell. The hormone is called the first messenger and the cAMP is termed the
second messenger. The hormone- receptor complex changes the permeability of the
cell membrane to facilitate the passage of materials through it. This increases
the activities of the cell as it receives the desired materials.
9. Match the following
:
Column I
Column II
(a) T4 (i)
Hypothalamus
(b) PTH (ii)Thyroid
(c) GnRH
(iii)Pituitary
(d) LH
(iv) Parathyroid.
Solution:
(a) – (ii); (b) – (iv); (c) – (i); (d) – (iii)